Sav1 - salvador family WW domain containing 1 Gene

Mus musculus

Also known as Sav; Salv; WW45; Wwp3; Wwp4; 1700040G09Rik

Gene ID: 64010 | Gene type: protein coding

About Sav1

Summary

Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Acts upstream of or within several processes, including epithelial cell differentiation; hippo signaling; and negative regulation of cell population proliferation. Predicted to be located in cytosol and nucleus. Predicted to be active in cell-cell junction; cytoplasm; and dendrite. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Used to study colonic disease and hepatocellular carcinoma. Orthologous to human SAV1 (salvador family WW domain containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Sav1 Products(1)

mRNA	Protein	Name
NM_022028.2	NP_071311.1	protein salvador homolog 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22292086	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21512031	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of or within hippo signaling	IGI IGI: Inferred from genetic interaction	18369314	MGI
acts upstream of or within hippo signaling	IMP IMP: Inferred from mutant phenotype	21512031	MGI
involved in hippo signaling	IMP IMP: Inferred from mutant phenotype	20080689	MGI
acts upstream of or within intestinal epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of keratinocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of or within keratinocyte differentiation	IGI IGI: Inferred from genetic interaction	18369314	MGI
acts upstream of or within keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of or within lung epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21512031	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of or within positive regulation of fat cell differentiation	IGI IGI: Inferred from genetic interaction	22292086	MGI
acts upstream of or within positive regulation of keratinocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of or within regulation of organ growth	IMP IMP: Inferred from mutant phenotype	21512031	MGI
acts upstream of or within regulation of stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of or within ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	21512031	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein salvador homolog 1

45 kDa WW domain protein	WW domain-containing protein 3
WW domain-containing protein 4	salvador homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12460	SAV1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18789	Sav1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25278	Sav1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sav1	NCBI	NCBI:60485

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