Mefv - MEFV innate immunity regulator, pyrin Gene

Rattus norvegicus

Also known as pyrin

Gene ID: 58923 | Gene type: protein coding

About Mefv

Summary

Predicted to enable actin binding activity; identical protein binding activity; and ubiquitin protein Ligase activity. Involved in response to lipopolysaccharide and response to silicon dioxide. Predicted to be located in nucleus. Predicted to be part of microtubule associated complex. Predicted to be active in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic Cancer (multiple). Orthologous to human MEFV (MEFV innate immuity regulator, pyrin). [provided by Alliance of Genome Resources, Apr 2022]

Mefv Products(1)

mRNA	Protein	Name
NM_031634.2	NP_113822.2	pyrin

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	16574623	RGD
involved in response to silicon dioxide	IEP IEP: Inferred from expression pattern	16574623	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pyrin

MEFV innate immuity regulator, pyrin	MEFV, pyrin innate immunity regulator
Mediterranean fever	marenostrin

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08313	MEFV Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20773	Mefv Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27287	Mefv Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mefv	NCBI	NCBI:4210

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