2. Gene
  3. OLFML3 - olfactomedin like 3 Gene

OLFML3 - olfactomedin like 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OLF44; HNOEL-iso

Gene ID: 56944 | Gene type: protein coding

About OLFML3

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:113,979,474-113,982,253 (from NCBI)

This gene has 5 transcripts (splice variants), 264 orthologues and 9 paralogues. Broad expression in ovary (RPKM 65.9), endometrium (RPKM 56.6) and 23 other tissues.

Summary

This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tissue remodeler with pro-angiogenic properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

OLFML3 Products(3)

mRNA Protein Name
NM_001286352.3 NP_001273281.1 olfactomedin-like protein 3 isoform 2
NM_001286353.3 NP_001273282.1 olfactomedin-like protein 3 isoform 3
NM_020190.5 NP_064575.1 olfactomedin-like protein 3 isoform 1 precursor

OLFML3 Protein Structure

OLF

OLF: Olfactomedin-like domain (138 - 400)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

olfactomedin-like protein 3

olfactomedin, 44-kd

Related Diseases

Diseases Alias
Alzheimer Disease 14

AD14

Alzheimer'S Disease 14

Alzheimer Disease-14

Alzheimer'S Disease 14, Late Onset
Myasthenic Syndrome, Congenital, 14

Congenital Myasthenic Syndrome 14

CMS14

Cmsta3

Myasthenic Syndrome, Congenital, With Tubular Aggregates 3

Myasthenic Syndrome, Congenital, 14, With Tubular Aggregates

Congenital Myasthenic Syndrome 14, With Tubular Aggregates

Congenital Myasthenic Syndrome With Tubular Aggregates 3

Myasthenic Syndrome, Congenital, With Tubular Aggregates, 3

Myasthenic Syndrome, Congenital, Type 14, With Tubular Aggregates
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09776 OLFML3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus OLFML3 VGNC VGNC:32424
Canis familiaris OLFML3 VGNC VGNC:44117
Mus musculus OLFML3 MGD MGI:1914877
Felis catus OLFML3 VGNC VGNC:63965
Macaca mulatta OLFML3 VGNC VGNC:75458
Rattus norvegicus OLFML3 RGD RGD:1311106
Others OLFML3 NCBI