Pias1 - protein inhibitor of activated STAT 1 Gene

Mus musculus

Also known as GBP; Ddxbp1; 2900068C24Rik

Gene ID: 56469 | Gene type: protein coding

About Pias1

Summary

Enables SUMO transferase activity and ubiquitin protein Ligase binding activity. Involved in several processes, including fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein sumoylation. Located in nucleus. Colocalizes with PML body. Is expressed in several structures, including branchial arch; genitourinary system; sensory organ; tooth; and trunk mesenchyme. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1). [provided by Alliance of Genome Resources, Apr 2022]

Pias1 Products(1)

mRNA	Protein	Name
NM_019663.3	NP_062637.2	E3 SUMO-protein ligase PIAS1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	24061474	MGI
enables SUMO ligase activity	IDA IDA: Inferred from direct assay	16600910	MGI
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	15123625	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14611647	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16600910	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16816390	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in fat cell differentiation	IDA IDA: Inferred from direct assay	24061474	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16127449	MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22406621	MGI
involved in positive regulation of protein localization to cell periphery	IDA IDA: Inferred from direct assay	16600910	MGI
involved in protein sumoylation	IDA IDA: Inferred from direct assay	22406621	MGI
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22406621	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with PML body	IDA IDA: Inferred from direct assay	22406621	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	34459572	MGI
located in nuclear periphery	IDA IDA: Inferred from direct assay	16600910	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16522640	MGI
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	34459572	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	34459572	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase PIAS1

DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1	DEAD/H box-binding protein 1
RING-type E3 ubiquitin transferase PIAS1	protein inhibitor of activated STAT protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W062696	BC-1382	Inhibitor	99.53%	Unkown
HY-RS10473	PIAS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20081	Pias1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26584	Pias1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pias1	NCBI	NCBI:8554

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