2. Gene
  3. Hes6 - hairy and enhancer of split 6 Gene

Hes6 - hairy and enhancer of split 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as bHLHb41

Gene ID: 55927 | Gene type: protein coding

About Hes6

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Acts upstream of or within cell differentiation; nervous system development; and regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Hes6 Products(3)

mRNA Protein Name
NM_001360899.1 NP_001347828.1 transcription cofactor HES-6 isoform 2
NM_001360900.1 NP_001347829.1 transcription cofactor HES-6 isoform 3
NM_019479.3 NP_062352.1 transcription cofactor HES-6 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11959828 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11959828 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11959828 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
10851137 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell differentiation IDA
IDA: Inferred from direct assay
11959828 MGI
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10851137 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11959828 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
10851137 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11959828 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10851137 MGI
Cellular Component GO Annotation Evidence Reference Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
10851137 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription cofactor HES-6

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10365 VPM-p15 Agonist 98.18% Unkown
HY-RS06139 HES6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20287 Hes6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26795 Hes6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hes6 NCBI NCBI:55502