2. Gene
  3. Calcrl - calcitonin receptor-like Gene

Calcrl - calcitonin receptor-like Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CRLR

Gene ID: 54598 | Gene type: protein coding

About Calcrl

Summary

Enables Calcitonin gene-related peptide receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; heart development; and positive regulation of smooth muscle cell proliferation. Predicted to be located in endoplasmic reticulum; endosome; and lysosome. Predicted to be part of CGRP Receptor complex and Adrenomedullin receptor complex. Predicted to be active in plasma membrane. Is expressed in dorsal root ganglion and lung epithelium. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CALCRL (Calcitonin receptor like receptor). [provided by Alliance of Genome Resources, Apr 2022]

Calcrl Products(1)

mRNA Protein Name
NM_018782.2 NP_061252.2 calcitonin gene-related peptide type 1 receptor precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables calcitonin gene-related peptide receptor activity IGI
IGI: Inferred from genetic interaction
8582325 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8582325 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16537897 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
16537897 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16537897 MGI
acts upstream of or within positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
16537897 MGI
acts upstream of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
16537897 MGI
acts upstream of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
16537897 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcitonin gene-related peptide type 1 receptor

CGRP type 1 receptor

calcitonin receptor-like receptor

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01835 CALCRL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20140 Calcrl Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26644 Calcrl Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Calcrl NCBI NCBI:10203