2. Gene
  3. RAPGEFL1 - Rap guanine nucleotide exchange factor like 1 Gene

RAPGEFL1 - Rap guanine nucleotide exchange factor like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Link-GEFII

Gene ID: 51195 | Gene type: protein coding

About RAPGEFL1

This gene has 11 transcripts (splice variants), 195 orthologues and 24 paralogues. Biased expression in skin (RPKM 52.1), esophagus (RPKM 22.9) and 7 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and nervous system development. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

RAPGEFL1 Products(3)

mRNA Protein Name
NM_001303533.2 NP_001290462.1 rap guanine nucleotide exchange factor-like 1 isoform 1
NM_001303534.3 NP_001290463.1 rap guanine nucleotide exchange factor-like 1 isoform 2
NM_016339.6 NP_057423.2 rap guanine nucleotide exchange factor-like 1 isoform 3

RAPGEFL1 Protein Structure

RasGEF

RasGEF: RasGEF domain (217 - 398)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
Protein Preferred Names Protein Names

rap guanine nucleotide exchange factor-like 1

Link guanine nucleotide exchange factor II

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 28

DFNA28

Autosomal Dominant Nonsyndromic Deafness 28

Autosomal Dominant Deafness 28

Deafness, Autosomal Dominant, 28

Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 28

Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 28

Deafness, Autosomal Dominant, Type 28
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11666 RAPGEFL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RAPGEFL1 VGNC VGNC:33727
Felis catus RAPGEFL1 VGNC VGNC:64494
Rattus norvegicus RAPGEFL1 RGD RGD:1563269
Macaca mulatta RAPGEFL1 VGNC VGNC:76501
Mus musculus RAPGEFL1 MGD MGI:3611446