Smad4 - SMAD family member 4 Gene

Rattus norvegicus

Also known as Madh4

Gene ID: 50554 | Gene type: protein coding

About Smad4

Summary

Enables DNA binding activity; SMAD binding activity; and filamin binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to glucose stimulus; and positive regulation of cardiac muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study pulmonary fibrosis. Biomarker of several diseases, including artery disease (multiple); gastrointestinal system Cancer (multiple); lung disease (multiple); prostatitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ Cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (Smad Family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Smad4 Products(1)

mRNA	Protein	Name
NM_019275.3	NP_062148.1	mothers against decapentaplegic homolog 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16959941	RGD
enables SMAD binding	IPI IPI: Inferred from physical interaction	16959941	RGD
enables filamin binding	IPI IPI: Inferred from physical interaction	20167606	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15153551	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16959941	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	11401854	RGD
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	12844345	RGD
involved in cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	26873969	RGD
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	24941801	RGD
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	20097766	RGD
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19940863	RGD
involved in ovarian follicle development	IEP IEP: Inferred from expression pattern	15698987	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15949472	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	16959941	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mothers against decapentaplegic homolog 4

MAD (mothers against decapentaplegic Drosophila) homolog 4	MAD homolog 4
SMAD 4	mothers against DPP homolog 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149414	MY-673		98.60%	Unkown
HY-RS13395	SMAD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17346	Smad4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23800	Smad4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smad4	NCBI	NCBI:4089

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