Ero1a - endoplasmic reticulum oxidoreductase 1 alpha Gene

Mus musculus

Also known as Ero1l; ERO1-L

Gene ID: 50527 | Gene type: protein coding

About Ero1a

Summary

This gene encodes a member of the endoplasmic reticulum oxidoreductin family. The encoded protein is localized to the endoplasmic reticulum and promotes the formation of disulfide bonds by oxidizing protein disulfide isomerase. This gene may play a role in endoplasmic reticulum stress-induced Apoptosis and the cellular response to hypoxia. [provided by RefSeq, Feb 2011]

Ero1a Products(1)

mRNA	Protein	Name
NM_015774.3	NP_056589.1	ERO1-like protein alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	15601821	MGI
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	20308425	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within L-ascorbic acid metabolic process	IMP IMP: Inferred from mutant phenotype	28106121	MGI
acts upstream of or within brown fat cell differentiation	IDA IDA: Inferred from direct assay	18492766	MGI
acts upstream of or within cell redox homeostasis	IGI IGI: Inferred from genetic interaction	23589496	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	28106121	MGI
acts upstream of or within endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	15601821	MGI
acts upstream of or within extracellular matrix organization	IGI IGI: Inferred from genetic interaction	22981861	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	19752026	MGI
acts upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IGI IGI: Inferred from genetic interaction	22981861	MGI
acts upstream of or within protein folding	IDA IDA: Inferred from direct assay	15601821	MGI
acts upstream of or within protein maturation by protein folding	IGI IGI: Inferred from genetic interaction	22981861	MGI
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	19752026	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	19752026	MGI
acts upstream of or within response to oxidative stress	IDA IDA: Inferred from direct assay	25452428	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	28106121	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28106121	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	28106121	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ERO1-like protein alpha

ERO1-L-alpha	ERO1-like
endoplasmic oxidoreductin-1-like protein	endoplasmic reticulum oxidation 1
endoplasmic reticulum oxidoreductase alpha	endoplasmic reticulum oxidoreductin-1-like protein
oxidoreductin-1-L-alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04511	ERO1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21564	Ero1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28082	Ero1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ero1a	NCBI	NCBI:30001

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