WEE2 - WEE2 oocyte meiosis inhibiting kinase Gene

Homo sapiens

Also known as OOMD5; WEE1B

Gene ID: 494551 | Gene type: protein coding

About WEE2

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:141,708,353-141,731,271 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 197 orthologues, 8 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable protein tyrosine kinase activity. Predicted to be involved in several processes, including female pronucleus assembly; negative regulation of oocyte maturation; and regulation of meiosis I. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

WEE2 Products(1)

mRNA	Protein	Name
NM_001105558.1	NP_001099028.1	wee1-like protein kinase 2

WEE2 Protein Structure

Pkinase

0
100
200
300
400
500
567 a.a.

Protein Preferred Names

Protein Names

wee1-like protein kinase 2

WEE1 homolog 2

Related Diseases

Diseases

Alias

Oocyte Maturation Defect 5

OOMD5

Female Infertility Due To Oocyte Meiotic Arrest

Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103029	Bosutinib isomer	Inhibitor	99.62%	Unkown
HY-RS15808	WEE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WEE2	VGNC	VGNC:84758
Bos taurus	WEE2	VGNC	VGNC:36931
Rattus norvegicus	WEE2	RGD	RGD:1587197
Mus musculus	WEE2	MGD	MGI:3027899
Canis familiaris	WEE2	VGNC	VGNC:48403
Felis catus	WEE2	VGNC	VGNC:67070
Others	WEE2	NCBI

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