Atg5 - autophagy related 5 Gene

Rattus norvegicus

Gene ID: 365601 | Gene type: protein coding

About Atg5

Summary

Involved in several processes, including chaperone-mediated autophagy; response to fluoride; and response to iron(II) ion. Located in axon. Part of protein-containing complex. Biomarker of ischemia. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (Autophagy related 5). [provided by Alliance of Genome Resources, Apr 2022]

Atg5 Products(4)

mRNA	Protein	Name
NM_001014250.2	NP_001014272.1	autophagy protein 5 isoform 1
NM_001399019.1	NP_001385948.1	autophagy protein 5 isoform 2
NM_001399020.1	NP_001385949.1	autophagy protein 5 isoform 3
NM_001399021.1	NP_001385950.1	autophagy protein 5 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18059433	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	16420522	RGD
involved in autophagy	IMP IMP: Inferred from mutant phenotype	18059433	RGD
involved in chaperone-mediated autophagy	IMP IMP: Inferred from mutant phenotype	23434281	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20075199	RGD
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	30715741	RGD
involved in positive regulation of stress granule assembly	IMP IMP: Inferred from mutant phenotype	30404558	RGD
involved in response to fluoride	IEP IEP: Inferred from expression pattern	24296261	RGD
involved in response to iron(II) ion	IEP IEP: Inferred from expression pattern	23187302	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	25040536	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28231469	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	18059433	RGD
is active in synapse	IDA IDA: Inferred from direct assay	28231469	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

autophagy protein 5

ATG5 autophagy related 5 homolog

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W018791	Bifendate		99.91%	Unkown
HY-N0538	Xylitol		≥98.0%	Yes

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151914	Antitumor agent-82	Inducer	/	Unkown
HY-157548	Antitumor agent-133	Inducer	/	Unkown
HY-167843	Alborixin	Inhibitor	/	Unkown
HY-170594	Antitumor agent-192	Inducer	/	Unkown
HY-173133	Antitumor agent-199		/	Unkown
HY-RS01152	ATG5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17532	Atg5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23989	Atg5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atg5	NCBI	NCBI:9474

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