2. Gene
  3. Spast - spastin Gene

Spast - spastin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Spg4

Gene ID: 362700 | Gene type: protein coding

About Spast

Summary

Predicted to enable microtubule-severing ATPase activity and tubulin binding activity. Predicted to be involved in several processes, including axonal transport; microtubule Cytoskeleton organization; and protein complex oligomerization. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum tubular network; and nucleus. Predicted to be active in microtubule Cytoskeleton. Predicted to colocalize with endoplasmic reticulum; endosome; and midbody. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin). [provided by Alliance of Genome Resources, Apr 2022]

Spast Products(1)

mRNA Protein Name
NM_001108702.2 NP_001102172.2 spastin
Protein Preferred Names Protein Names

spastin

spastic paraplegia 4 (autosomal dominant

spastic paraplegia 4 (autosomal dominant

spastin)

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13634 SPAST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19038 Spast Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25527 Spast Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spast NCBI NCBI:6683
Mus musculus Spast NCBI NCBI:50850