Map1lc3a - microtubule-associated protein 1 light chain 3 alpha Gene

Rattus norvegicus

Also known as LC3A; LC3-I; LC3-II

Gene ID: 362245 | Gene type: protein coding

About Map1lc3a

Summary

Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; cellular response to copper ion; and response to morphine. Located in autophagosome membrane; cytosol; and late endosome. Is active in synapse. Biomarker of several diseases, including artery disease (multiple); degenerative disc disease; ischemia (multiple); retinal detachment; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Map1lc3a Products(1)

mRNA	Protein	Name
NM_199500.2	NP_955794.1	microtubule-associated proteins 1A/1B light chain 3A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22421968	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	27769861	RGD
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	27769861	RGD
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	11060023	RGD
involved in autophagy	IDA IDA: Inferred from direct assay	16420522	RGD
involved in cellular response to amino acid starvation	IEP IEP: Inferred from expression pattern	22835012	RGD
involved in cellular response to copper ion	IEP IEP: Inferred from expression pattern	22540380	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	23314838	RGD
involved in cellular response to oxygen-glucose deprivation	IEP IEP: Inferred from expression pattern	27769861	RGD
involved in p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	27769861	RGD
involved in response to iron(II) ion	IEP IEP: Inferred from expression pattern	23187302	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	22927075	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	17665967	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IDA IDA: Inferred from direct assay	11060023	RGD
located in autophagosome membrane	IDA IDA: Inferred from direct assay	16300744	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	11060023	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15095872	RGD
located in late endosome	IDA IDA: Inferred from direct assay	19337031	RGD
located in organelle membrane	IDA IDA: Inferred from direct assay	11060023	RGD
is active in synapse	EXP EXP: Inferred from Experiment	21797867	RGD
is active in synapse	IDA IDA: Inferred from direct assay	15095872	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

microtubule-associated proteins 1A/1B light chain 3A

MAP1 light chain 3-like protein 1	MAP1A/1B light chain 3 A
MAP1A/MAP1B LC3 A	MAP1A/MAP1B light chain 3 A
autophagy-related protein LC3 A	autophagy-related ubiquitin-like modifier LC3 A

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08028	MAP1LC3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21273	Map1lc3a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27792	Map1lc3a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map1lc3a	NCBI	NCBI:84557

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