2. Gene
  3. Sufu - SUFU negative regulator of hedgehog signaling Gene

Sufu - SUFU negative regulator of hedgehog signaling Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 361769 | Gene type: protein coding

About Sufu

Summary

Predicted to enable beta-catenin binding activity and protein kinase binding activity. Predicted to be involved in cytoplasmic sequestering of transcription factor. Predicted to act upstream of with a negative effect on smoothened signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; negative regulation of nitrogen compound metabolic process; and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Predicted to be located in cilium and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of Hedgehog signaling). [provided by Alliance of Genome Resources, Apr 2022]

Sufu Products(1)

mRNA Protein Name
NM_001024899.1 NP_001020070.1 suppressor of fused homolog
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cellular response to drug IEP
IEP: Inferred from expression pattern
30790292 RGD
involved in spermatid development IEP
IEP: Inferred from expression pattern
21893610 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

suppressor of fused homolog

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-105634A Nomegestrol acetate Agonist 99.94% Yes
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162273 Antibacterial agent 189 Inhibitor / Unkown
HY-RS14007 SUFU Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18155 Sufu Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24629 Sufu Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sufu NCBI NCBI:51684