Zic2 - Zic family member 2 Gene

About Zic2

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Predicted to be involved in nervous system development; regulation of transcription, DNA-templated; and visual perception. Predicted to act upstream of or within several processes, including cilium organization; neural tube closure; and positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2). [provided by Alliance of Genome Resources, Apr 2022]