2. Gene
  3. Gsdme - gasdermin E Gene

Gsdme - gasdermin E Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Dfna5; Dfna5h

Gene ID: 353316 | Gene type: protein coding

About Gsdme

Summary

Predicted to enable cardiolipin binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and wide pore channel activity. Predicted to be involved in several processes, including cellular response to tumor necrosis factor; granzyme-mediated programmed cell death signaling pathway; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within inner ear receptor cell differentiation. Predicted to be located in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss. Orthologous to human GSDME (gasdermin E). [provided by Alliance of Genome Resources, Apr 2022]

Gsdme Products(1)

mRNA Protein Name
NM_001191749.1 NP_001178678.1 gasdermin-E
Protein Preferred Names Protein Names

gasdermin-E

DFNA5, deafness associated tumor suppressor

deafness, autosomal dominant 5 homolog

non-syndromic hearing impairment protein 5

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0621 Triclabendazole Inhibitor 99.36% Yes
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111770 2-Bromohexadecanoic acid Inhibitor 99.95% Unkown
HY-RS05858 GSDME Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-B0621S Triclabendazole-d3 / Unkown
HY-N15380 4,4′-Secalonic acid D / Unkown
HY-P10939 Ac-DMLD-CMK Inhibitor / Unkown
HY-RS16846 Gsdme Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23287 Gsdme Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsdme NCBI NCBI:1687