BRINP3 - BMP/retinoic acid inducible neural specific 3 Gene

Homo sapiens

Also known as FAM5C; DBCCR1L; DBCCR1L1

Gene ID: 339479 | Gene type: protein coding

About BRINP3

Cytogenetic location: 1q31.1 Genomic coordinates (GRCh38): 1:190,097,658-190,477,864 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Biased expression in brain (RPKM 4.5), small intestine (RPKM 2.0) and 6 other tissues.

Summary

This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric Cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

BRINP3 Products(2)

mRNA	Protein	Name
NM_001317188.2	NP_001304117.1	BMP/retinoic acid-inducible neural-specific protein 3 isoform 2
NM_199051.3	NP_950252.1	BMP/retinoic acid-inducible neural-specific protein 3 isoform 1 precursor

BRINP3 Protein Structure

MACPF

0
200
400
600
766 a.a.

Protein Preferred Names

Protein Names

BMP/retinoic acid-inducible neural-specific protein 3

DBCCR1-like protein 1

Related Diseases

Diseases

Alias

Tongue Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Tongue

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Aggressive Periodontitis

Juvenile Periodontitis	Periodontitis, Juvenile
Prepubertal Periodontitis

Colitis

Optic Nerve Glioma

Glioma Of The Optic Nerve

Optic Nerve Neoplasm

Optic Nerve Neoplasms	Neoplasm Of Optic Nerve
Tumor Of Second Cranial Nerve	Tumour Of Optic Nerve

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01622	BRINP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BRINP3	VGNC	VGNC:60176
Macaca mulatta	BRINP3	VGNC	VGNC:70363
Bos taurus	BRINP3	VGNC	VGNC:26568
Canis familiaris	BRINP3	VGNC	VGNC:38529
Mus musculus	BRINP3	MGD	MGI:2443035
Rattus norvegicus	BRINP3	RGD	RGD:708421

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