Slc11a1 - solute carrier family 11 member 1 Gene

Also known as Bcg; Itg; Lsh; Nramp1

About Slc11a1

Summary

Predicted to enable metal ion transmembrane transporter activity and protein homodimerization activity. Predicted to be involved in cellular transition metal ion homeostasis; metal ion transport; and response to lipopolysaccharide. Predicted to act upstream of or within several processes, including cation transport; defense response to Other organism; and positive regulation of macromolecule metabolic process. Predicted to be located in cytoplasmic vesicle and lysosome. Predicted to be active in phagocytic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Buruli ulcer disease; autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1). [provided by Alliance of Genome Resources, Apr 2022]