2. Gene
  3. Setd2 - SET domain containing 2, histone lysine methyltransferase Gene

Setd2 - SET domain containing 2, histone lysine methyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 316013 | Gene type: protein coding

About Setd2

Summary

Predicted to enable alpha-tubulin binding activity and Histone Methyltransferase activity (H3-K36 specific). Predicted to be involved in several processes, including defense response to Other organism; nucleic acid metabolic process; and peptidyl-lysine methylation. Predicted to act upstream of or within several processes, including animal organ development; histone H3-K36 trimethylation; and tube morphogenesis. Predicted to be located in chromosome and nucleus. Human ortholog(s) of this gene implicated in carcinoma (multiple); gastrointestinal system Cancer (multiple); idiopathic pulmonary fibrosis; and malignant mesothelioma. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Setd2 Products(1)

mRNA Protein Name
NM_001401163.1 NP_001388092.1 histone-lysine N-methyltransferase SETD2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of ossification IMP
IMP: Inferred from mutant phenotype
30746871 RGD
involved in response to alkaloid IEP
IEP: Inferred from expression pattern
27846294 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
30746871 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27766425 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SETD2

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-136328 EZM0414 TFA Inhibitor 97.20% Phase 1
HY-144858 EZM0414 Inhibitor 99.11% Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139626 EPZ-719 Inhibitor 99.85% Unkown
HY-RS12742 SETD2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-124699 MMSET-IN-1 Inhibitor / Unkown
HY-P10463 ssK36 Inhibitor / Unkown
HY-RS16976 Setd2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23419 Setd2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Setd2 NCBI NCBI:29072