2. Gene
  3. Manf - mesencephalic astrocyte-derived neurotrophic factor Gene

Manf - mesencephalic astrocyte-derived neurotrophic factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Armet

Gene ID: 315989 | Gene type: protein coding

About Manf

Summary

Predicted to enable sulfatide binding activity. Predicted to be involved in dopaminergic neuron differentiation; neuron projection development; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure. Located in extracellular space and perinuclear region of cytoplasm. Colocalizes with endoplasmic reticulum. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic Cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Manf Products(1)

mRNA Protein Name
NM_001401064.1 NP_001387993.1 mesencephalic astrocyte-derived neurotrophic factor precursor
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
19641128 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19641128 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mesencephalic astrocyte-derived neurotrophic factor

arginine-rich protein

arginine-rich, mutated in early stage tumors

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08017 MANF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18040 Manf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24514 Manf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Manf NCBI NCBI:7873
Mus musculus Manf NCBI NCBI:74840