2. Gene
  3. Lrrc8a - leucine rich repeat containing 8 VRAC subunit A Gene

Lrrc8a - leucine rich repeat containing 8 VRAC subunit A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Lrrc8

Gene ID: 311846 | Gene type: protein coding

About Lrrc8a

Summary

Enables volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; response to osmotic stress; and taurine transport. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Lrrc8a Products(1)

mRNA Protein Name
NM_001024782.1 NP_001019953.1 volume-regulated anion channel subunit LRRC8A
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables volume-sensitive anion channel activity IMP
IMP: Inferred from mutant phenotype
28833202 RGD
Biological Process GO Annotation Evidence Reference Source
involved in aspartate transmembrane transport IMP
IMP: Inferred from mutant phenotype
28833202 RGD
involved in response to osmotic stress IMP
IMP: Inferred from mutant phenotype
28833202 RGD
involved in taurine transmembrane transport IMP
IMP: Inferred from mutant phenotype
28833202 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

volume-regulated anion channel subunit LRRC8A

leucine rich repeat containing 8 family, member A

leucine rich repeat containing 8A

leucine-rich repeat-containing 8

leucine-rich repeat-containing protein 8A

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07827 LRRC8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21148 Lrrc8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27665 Lrrc8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrc8a NCBI NCBI:56262