Muc4 - mucin 4, cell surface associated Gene

Rattus norvegicus

Also known as Psmc; ASGP-1

Gene ID: 303887 | Gene type: protein coding

About Muc4

Summary

Enables ErbB-2 class receptor binding activity. Involved in several processes, including estrous cycle; negative regulation of T cell mediated cytotoxicity directed against tumor cell target; and negative regulation of cell adhesion. Located in several cellular components, including apical plasma membrane; extracellular space; and microvillus membrane. Part of protein-containing complex. Colocalizes with endoplasmic reticulum. Biomarker of cholangiocarcinoma; corneal neovascularization; mucositis; and otitis media. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human MUC4 (Mucin 4, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]

Muc4 Products(1)

mRNA	Protein	Name
XM_039088927.1	XP_038944855.1	mucin-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ErbB-2 class receptor binding	IPI IPI: Inferred from physical interaction	15499570	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	20054827	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	10980611	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	9857062	RGD
involved in digestive tract development	IEP IEP: Inferred from expression pattern	15389518	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	9618151	RGD
involved in lactation	IEP IEP: Inferred from expression pattern	15499570	RGD
involved in mammary gland development	IEP IEP: Inferred from expression pattern	15499570	RGD
involved in negative regulation of T cell mediated cytotoxicity directed against tumor cell target	IDA IDA: Inferred from direct assay	10232613	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19293191	RGD
involved in negative regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	9407114	RGD
involved in negative regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	9407114	RGD
involved in post-embryonic camera-type eye development	IEP IEP: Inferred from expression pattern	11120573	RGD
involved in regulation of signaling receptor activity	IDA IDA: Inferred from direct assay	10026131	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	12668667	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	9618151	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	17495032	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	9618151	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	10634605	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18998135	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15499570	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	12186632	RGD
located in microvillus membrane	IDA IDA: Inferred from direct assay	2674161	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	20054827	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mucin-4

ASGP	MUC-4
ascites sialoglycoprotein	pancreatic adenocarcinoma mucin
pre-sialomucin complex	sialomucin ascites sialoglycoprotein-1
sialomucin complex	testis mucin

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS19923	Muc4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08843	MUC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26425	Muc4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Muc4	NCBI	NCBI:4585

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