Kcnq3 - potassium voltage-gated channel subfamily Q member 3 Gene

Rattus norvegicus

Gene ID: 29682 | Gene type: protein coding

About Kcnq3

Summary

Enables several functions, including Calmodulin binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in cellular response to ammonium ion; nervous system development; and potassium ion transmembrane transport. Located in several cellular components, including axon initial segment; membrane raft; and neuronal cell body. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq3 Products(1)

mRNA	Protein	Name
NM_031597.5	NP_113785.4	potassium voltage-gated channel subfamily KQT member 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calmodulin binding	IDA IDA: Inferred from direct assay	24333508	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15304482	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	24333508	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	17322297	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	9836639	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to ammonium ion	IMP IMP: Inferred from mutant phenotype	24333508	RGD
involved in ganglion development	IEP IEP: Inferred from expression pattern	12832524	RGD
involved in monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	15304482	RGD
involved in oligodendrocyte development	IEP IEP: Inferred from expression pattern	21750731	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	9836639	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon initial segment	IDA IDA: Inferred from direct assay	24333508	RGD
located in cell surface	IDA IDA: Inferred from direct assay	15304482	RGD
located in dendrite	IDA IDA: Inferred from direct assay	24333508	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12832524	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	9836639	RGD
located in somatodendritic compartment	IDA IDA: Inferred from direct assay	24333508	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	9836639	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily KQT member 3

KQT-like 3	potassium channel subunit alpha KvLQT3
potassium channel, voltage-gated KQT-like subfamily Q, member 3	potassium voltage-gated channel, KQT-like subfamily, member 3
voltage-gated potassium channel subunit Kv7.3

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108577	XE991 dihydrochloride	Inhibitor	99.63%	Unkown
HY-122114	ICA-27243	Activator	99.27%	Unkown
HY-108577A	XE991	Inhibitor	99.62%	Unkown
HY-130070	QO-40	Activator	98.77%	Unkown
HY-RS07175	KCNQ3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19700	Kcnq3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26195	Kcnq3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnq3	NCBI	NCBI:3786

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