Ptpn5 - protein tyrosine phosphatase, non-receptor type 5 Gene

Rattus norvegicus

Also known as STEP

Gene ID: 29644 | Gene type: protein coding

About Ptpn5

Summary

Enables several functions, including identical protein binding activity; mitogen-activated protein kinase binding activity; and protein tyrosine Phosphatase activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of intracellular protein transport; and regulation of protein phosphorylation. Located in several cellular components, including perikaryon; proximal dendrite; and synaptic vesicle. Used to study transient cerebral ischemia. Biomarker of transient cerebral ischemia. Orthologous to human PTPN5 (protein tyrosine Phosphatase non-receptor type 5). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn5 Products(1)

mRNA	Protein	Name
NM_001398605.1	NP_001385534.1	tyrosine-protein phosphatase non-receptor type 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	27103516	RGD
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	19625523	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in exploration behavior	IDA IDA: Inferred from direct assay	17008368	RGD
involved in negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	9857190	RGD
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	9857190	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	19026408	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	10101226	RGD
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	12483215	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19625523	RGD
involved in positive regulation of protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	19625523	RGD
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	19625523	RGD
involved in positive regulation of response to drug	IMP IMP: Inferred from mutant phenotype	19026408	RGD
involved in regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19625523	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	23711322	RGD
involved in response to immobilization stress	IDA IDA: Inferred from direct assay	17008368	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17623046	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	7869116	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8331384	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	10101226	RGD
located in proximal dendrite	IDA IDA: Inferred from direct assay	8331384	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	27103516	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	27103516	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 5

neural-specific protein-tyrosine phosphatase	protein-tyrosine phosphatase striatum-enriched
protein-tyrosine-phosphatase non-receptor 5	striatum-enriched protein-tyrosine phosphatase

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141800	MurA-IN-1	Inhibitor	99.32%	Unkown
HY-RS11428	PTPN5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20091	Ptpn5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26594	Ptpn5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptpn5	NCBI	NCBI:84867

Name
Email *

	Sorry, but the email address you supplied was invalid.