2. Gene
  3. Bckdk - branched chain ketoacid dehydrogenase kinase Gene

Bckdk - branched chain ketoacid dehydrogenase kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 29603 | Gene type: protein coding

About Bckdk

Summary

Enables ATP binding activity; [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity; and protein serine/threonine kinase activity. Involved in branched-chain amino acid catabolic process; phosphorylation; and spermatogenesis. Part of mitochondrial alpha-ketoglutarate dehydrogenase complex. Used to study branched-chain keto acid dehydrogenase kinase deficiency and oligospermia. Human ortholog(s) of this gene implicated in branched-chain keto acid dehydrogenase kinase deficiency. Orthologous to human BCKDK (branched chain keto acid dehydrogenase kinase). [provided by Alliance of Genome Resources, Apr 2022]

Bckdk Products(1)

mRNA Protein Name
NM_019244.2 NP_062117.2 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
1377677 RGD
enables [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity IMP
IMP: Inferred from mutant phenotype
1377677 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
1377677 RGD
Biological Process GO Annotation Evidence Reference Source
involved in L-leucine catabolic process IMP
IMP: Inferred from mutant phenotype
27472223 RGD
involved in branched-chain amino acid catabolic process IDA
IDA: Inferred from direct assay
1377677 RGD
involved in isoleucine catabolic process IMP
IMP: Inferred from mutant phenotype
27472223 RGD
involved in phosphorylation IDA
IDA: Inferred from direct assay
1377677 RGD
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
27472223 RGD
involved in valine catabolic process IMP
IMP: Inferred from mutant phenotype
27472223 RGD
Cellular Component GO Annotation Evidence Reference Source
part of oxoglutarate dehydrogenase complex IDA
IDA: Inferred from direct assay
1377677 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

BCKD-kinase

BCKDHKIN

branched-chain alpha-ketoacid dehydrogenase kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01411 BCKDK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19988 Bckdk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26492 Bckdk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bckdk NCBI NCBI:10295