Hes1 - hes family bHLH transcription factor 1 Gene

Rattus norvegicus

Gene ID: 29577 | Gene type: protein coding

About Hes1

Summary

Enables several functions, including JUN kinase binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including cellular response to cytokine stimulus; generation of neurons; and regulation of gene expression. Located in chromatin and nuclear matrix. Used to study chronic myeloid leukemia and epilepsy. Biomarker of acute kidney failure. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hes1 Products(1)

mRNA	Protein	Name
NM_024360.4	NP_077336.3	transcription factor HES-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9389649	RGD
enables E-box binding	IDA IDA: Inferred from direct assay	19670267	RGD
enables JUN kinase binding	IPI IPI: Inferred from physical interaction	22302822	RGD
enables N-box binding	IDA IDA: Inferred from direct assay	22302822	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	15607978	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	9389649	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8687460	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11238932	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11486045	RGD
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	8687460	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	19272428	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	23589286	RGD
involved in cellular response to nerve growth factor stimulus	IMP IMP: Inferred from mutant phenotype	9389649	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	23589286	RGD
involved in forebrain radial glial cell differentiation	IDA IDA: Inferred from direct assay	11399758	RGD
involved in hair cell differentiation	IMP IMP: Inferred from mutant phenotype	11023859	RGD
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8649374	RGD
involved in negative regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	22302822	RGD
involved in negative regulation of forebrain neuron differentiation	IDA IDA: Inferred from direct assay	11399758	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19670267	RGD
involved in negative regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	11399758	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	9389649	RGD
involved in negative regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	12666205	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8649374	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11486045	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	9634594	RGD
involved in neuronal stem cell population maintenance	IDA IDA: Inferred from direct assay	11399758	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15607978	RGD
involved in positive regulation of glial cell differentiation	IMP IMP: Inferred from mutant phenotype	10839357	RGD
involved in regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	22302822	RGD
involved in response to alkaloid	IEP IEP: Inferred from expression pattern	23545940	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	15862623	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	15862623	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	15607978	RGD
located in nuclear matrix	IDA IDA: Inferred from direct assay	11035023	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor HES-1

RHL	hairy and enhancer of split 1
hairy-like protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19369	L-685458		99.48%	Unkown
HY-117113	JI051	Inhibitor	≥98.0%	Unkown
HY-107245	Segetalin B		99.51%	Unkown
HY-164410	MO-I-1100	Inhibitor	99.76%	Unkown
HY-124484	JI130	Inhibitor	99.01%	Unkown
HY-RS06134	HES1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N3393	Lethedioside A		/	Unkown
HY-RS17070	Hes1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23514	Hes1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hes1	NCBI	NCBI:3280

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