Men1 - menin 1 Gene

Rattus norvegicus

Also known as menin

Gene ID: 29417 | Gene type: protein coding

About Men1

Summary

Enables chromatin binding activity. Involved in several processes, including animal organ development; regulation of epithelial cell proliferation; and regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in endocrine gland Cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Apr 2022]

Men1 Products(1)

mRNA	Protein	Name
NM_019208.3	NP_062081.1	menin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	24157940	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	22166975	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	21239441	RGD
involved in decidualization	IEP IEP: Inferred from expression pattern	19780023	RGD
involved in negative regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	15054094	RGD
involved in negative regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	15054094	RGD
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15054094	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22120711	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24157940	RGD
involved in regulation of activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15031321	RGD
involved in regulation of type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	24157940	RGD
involved in response to transforming growth factor beta	IMP IMP: Inferred from mutant phenotype	15054094	RGD
involved in type B pancreatic cell differentiation	IMP IMP: Inferred from mutant phenotype	24157940	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10612420	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

menin

multiple endocrine neoplasia 1	multiple endocrine neoplasia I
multiple endocrine neoplasia type I

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151595	Menin-MLL inhibitor-22	Inhibitor	99.85%	Unkown
HY-103304	CGRP antagonist 4	Antagonist	/	Unkown
HY-168182	Menin-MLL inhibitor 34	Inhibitor	/	Unkown
HY-172416	Balomenib	Inhibitor	/	Unkown
HY-RS08333	MEN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18140	Men1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24615	Men1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Men1	NCBI	NCBI:4221

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