Adra1a - adrenoceptor alpha 1A Gene

Rattus norvegicus

Also known as Adra1c

Gene ID: 29412 | Gene type: protein coding

About Adra1a

Summary

Enables alpha1-adrenergic receptor activity. Involved in several processes, including activation of Phospholipase C activity; positive regulation of cell communication; and regulation of blood circulation. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and Z disc. Is active in GABA-ergic synapse; dopaminergic synapse; and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study bladder neck obstruction. Biomarker of hypertension and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A). [provided by Alliance of Genome Resources, Apr 2022]

Adra1a Products(1)

mRNA	Protein	Name
NM_017191.2	NP_058887.2	alpha-1A adrenergic receptor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	18332105	RGD
involved in phospholipase C-activating adrenergic receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19011682	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19011682	RGD
involved in positive regulation of action potential	IMP IMP: Inferred from mutant phenotype	17337632	RGD
involved in positive regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	19011682	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	17588332	RGD
involved in positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	22040923	RGD
involved in positive regulation of protein kinase C signaling	IDA IDA: Inferred from direct assay	18467629	RGD
involved in positive regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	19041301	RGD
involved in positive regulation of synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	14532911	RGD
involved in positive regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	22040923	RGD
involved in positive regulation of vasoconstriction	IDA IDA: Inferred from direct assay	15877108	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	19011682	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	12548707	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	12548707	RGD
involved in response to hormone	IMP IMP: Inferred from mutant phenotype	11684150	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	17588332	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	22588352	RGD
located in T-tubule	IDA IDA: Inferred from direct assay	18467629	RGD
located in Z disc	IDA IDA: Inferred from direct assay	18467629	RGD
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	22588352	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	12548707	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12548707	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	22588352	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	22588352	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-1A adrenergic receptor

adrenergic alpha 1c receptor	adrenergic receptor alpha 1c subtype
adrenergic receptor, alpha 1a	adrenergic receptor, alpha 1c
adrenergic, alpha-1A-, receptor	alpha-1A adrenoceptor
alpha-1A adrenoreceptor	alpha-1C adrenergic receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00408	ADRA1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21088	Adra1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27606	Adra1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adra1a	NCBI	NCBI:148

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