Oprk1 - opioid receptor, kappa 1 Gene

Rattus norvegicus

Gene ID: 29335 | Gene type: protein coding

About Oprk1

Summary

This gene encodes an Opioid Receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of Adenylate Cyclase activity and neurotransmitter release. This Opioid Receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Oprk1 Products(2)

mRNA	Protein	Name
NM_001318742.1	NP_001305671.1	kappa-type opioid receptor isoform 1x
NM_017167.3	NP_058863.1	kappa-type opioid receptor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21041644	RGD
enables receptor serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	27865836	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	24919534	RGD
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	27865836	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	9645969	RGD
involved in conditioned place preference	IMP IMP: Inferred from mutant phenotype	21549821	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	11961051	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	21041644	RGD
involved in maternal behavior	IDA IDA: Inferred from direct assay	22641418	RGD
involved in negative regulation of luteinizing hormone secretion	IMP IMP: Inferred from mutant phenotype	23391862	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9572309	RGD
involved in positive regulation of dopamine secretion	IDA IDA: Inferred from direct assay	17568430	RGD
involved in positive regulation of eating behavior	IMP IMP: Inferred from mutant phenotype	17456590	RGD
involved in positive regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	16648139	RGD
involved in positive regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	12815037	RGD
involved in response to acrylamide	IEP IEP: Inferred from expression pattern	22197712	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	9645969	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	8904783	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	9645969	RGD
involved in response to insulin	IDA IDA: Inferred from direct assay	10995763	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	9645969	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	28509375	RGD
involved in sensory perception of temperature stimulus	IMP IMP: Inferred from mutant phenotype	21041644	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	26365878	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	17120286	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17120286	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	26365878	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17120286	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	17120286	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	11746715	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	11746715	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	26365878	RGD
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	26365878	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	11746715	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kappa-type opioid receptor

K-OR-1

KOR-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116163	ML350		/	Unkown
HY-RS09802	OPRK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21006	Oprk1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27523	Oprk1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Oprk1	NCBI	NCBI:4986

Name
Email *

	Sorry, but the email address you supplied was invalid.