2. Gene
  3. Nit1 - nitrilase 1 Gene

Nit1 - nitrilase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 289222 | Gene type: protein coding

About Nit1

Summary

The protein encoded by this gene is a member of the nitrilase enzyme superfamily. Nitrilases are nonpeptidic C-N hydrolases. In mammals, nitrilases form small molecule C-N bonds such as acid amides, carbamates and ureas. Nit1-deficient mice display phenotypes including increased cell proliferation, resistance to DNA damage, and an increased number of N-nitrosomethylbenzylamine-induced murine forestomach tumors, suggesting a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Nit1 Products(4)

mRNA Protein Name
NM_001082580.1 NP_001076049.1 deaminated glutathione amidase isoform b
NM_001305646.1 NP_001292575.1 deaminated glutathione amidase isoform c
NM_001305647.1 NP_001292576.1 deaminated glutathione amidase isoform b
NM_182668.2 NP_872609.2 deaminated glutathione amidase isoform a
Protein Preferred Names Protein Names

deaminated glutathione amidase

dGSH amidase

nitrilase homolog 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10622 SHLP-3 Inhibitor / Unkown
HY-P10625 SHLP-6 / Unkown
HY-RS09310 NIT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19359 Nit1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25851 Nit1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nit1 NCBI NCBI:4817