2. Gene
  3. CRKL - Crkl CRK like proto-oncogene, adaptor protein Gene

CRKL - Crkl CRK like proto-oncogene, adaptor protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 287942 | Gene type: protein coding

About CRKL

Summary

Predicted to enable several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of substrate adhesion-dependent cell spreading; and regulation of protein phosphorylation. Predicted to act upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and generation of neurons. Located in cytoplasm. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

CRKL Products(1)

mRNA Protein Name
NM_001008284.1 NP_001008285.1 crk-like protein
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10720695 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

crk-like protein

crk-like protein-like

v-crk avian sarcoma virus CT10 oncogene homolog-like

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125090 PHA-680626 / Unkown
HY-RS03185 CRKL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-164469 CHMFL-48 Inhibitor / Unkown
HY-RS19315 Crkl Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25806 Crkl Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CRKL NCBI NCBI:1399