2. Gene
  3. Cartpt - CART prepropeptide Gene

Cartpt - CART prepropeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cart

Gene ID: 27220 | Gene type: protein coding

About Cartpt

Summary

This gene encodes preproprotein isoforms that are processed into multiple biologically active peptides. Expression of this gene is regulated by cocaine and Other drugs, and is associated with feeding/appetite and stress response. Mice lacking the encoded protein are predisposed to obesity. Deficiency of the encoded protein in mice results in pancreatic islet dysfunction, impaired Insulin secretion and glucose intolerance. Alternative splicing results in multiple transcript variants encoding different isoforms, which are subsequently processed into mature peptides. [provided by RefSeq, Jul 2015]

Cartpt Products(2)

mRNA Protein Name
NM_001081493.2 NP_001074962.1 cocaine- and amphetamine-regulated transcript protein isoform 2 preproprotein
NM_013732.7 NP_038760.3 cocaine- and amphetamine-regulated transcript protein isoform 1 preproprotein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15908120 MGI
involved in adult feeding behavior IDA
IDA: Inferred from direct assay
9590691 MGI
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
9590691 MGI
involved in negative regulation of appetite IMP
IMP: Inferred from mutant phenotype
9590691 MGI
involved in negative regulation of bone resorption IGI
IGI: Inferred from genetic interaction
16614075 MGI
acts upstream of positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15908120 MGI
acts upstream of positive regulation of protein kinase activity IDA
IDA: Inferred from direct assay
15908120 MGI
acts upstream of or within regulation of bone remodeling IMP
IMP: Inferred from mutant phenotype
15724149 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
9590691 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cocaine- and amphetamine-regulated transcript protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01935 CARTPT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21831 Cartpt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28348 Cartpt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cartpt NCBI NCBI:9607