2. Gene
  3. Lrig2 - leucine-rich repeats and immunoglobulin-like domains 2 Gene

Lrig2 - leucine-rich repeats and immunoglobulin-like domains 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as LIG-2; 4632419I10Rik

Gene ID: 269473 | Gene type: protein coding

About Lrig2

Summary

Enables signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of axon regeneration; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of protein localization to cell surface. Located in several cellular components, including growth cone; intracellular vesicle; and neuronal cell body. Is expressed in several structures, including branchial arch; central nervous system; eye; inner ear; and nasal pit. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human LRIG2 (leucine rich repeats and immunoglobulin like domains 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrig2 Products(2)

mRNA Protein Name
NM_001025067.2 NP_001020238.1 leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 1 precursor
NM_001310698.1 NP_001297627.1 leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
26651291 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
26651291 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within innervation IGI
IGI: Inferred from genetic interaction
24086156 MGI
acts upstream of membrane protein ectodomain proteolysis IMP
IMP: Inferred from mutant phenotype
26651291 MGI
acts upstream of or within negative regulation of axon regeneration IMP
IMP: Inferred from mutant phenotype
26651291 MGI
acts upstream of or within negative regulation of membrane protein ectodomain proteolysis IMP
IMP: Inferred from mutant phenotype
26651291 MGI
acts upstream of or within negative regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
26651291 MGI
acts upstream of or within positive regulation of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
26651291 MGI
acts upstream of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
26651291 MGI
acts upstream of or within regulation of axon regeneration IGI
IGI: Inferred from genetic interaction
26651291 MGI
acts upstream of or within regulation of neuron migration IGI
IGI: Inferred from genetic interaction
26651291 MGI
acts upstream of or within regulation of platelet-derived growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
24023893 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
24086156 MGI
Cellular Component GO Annotation Evidence Reference Source
located in growth cone IDA
IDA: Inferred from direct assay
26651291 MGI
located in intracellular vesicle IDA
IDA: Inferred from direct assay
26651291 MGI
located in membrane IDA
IDA: Inferred from direct assay
26651291 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeats and immunoglobulin-like domains protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07788 LRIG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20982 Lrig2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27499 Lrig2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrig2 NCBI NCBI:9860