Foxl2 - forkhead box L2 Gene

Mus musculus

Also known as BPES; Pfrk; PINTO

Gene ID: 26927 | Gene type: protein coding

About Foxl2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and Estrogen receptor binding activity. Acts upstream of or within several processes, including positive regulation of gonadotropin secretion; regulation of transcription by RNA polymerase II; and reproductive structure development. Located in nucleus. Is expressed in several structures, including adenohypophysis; branchial arch; eye; future pituitary; and genitourinary system. Used to study blepharophimosis, ptosis, and epicanthus inversus syndrome. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2). [provided by Alliance of Genome Resources, Apr 2022]

Foxl2 Products(1)

mRNA	Protein	Name
NM_012020.2	NP_036150.1	forkhead box protein L2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12943993	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12943993	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12943993	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12943993	MGI
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	19797124	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16153597	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within embryonic eye morphogenesis	IMP IMP: Inferred from mutant phenotype	15056605	MGI
acts upstream of or within female gonad development	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within female somatic sex determination	IMP IMP: Inferred from mutant phenotype	15944199	MGI
acts upstream of or within granulosa cell differentiation	IMP IMP: Inferred from mutant phenotype	14736745	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21757499	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21757499	MGI
acts upstream of or within ovarian follicle development	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	14736745	MGI
acts upstream of or within positive regulation of follicle-stimulating hormone secretion	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within positive regulation of luteinizing hormone secretion	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12943993	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within single fertilization	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within uterus development	IGI IGI: Inferred from genetic interaction	24739304	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15056605	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein L2

P-Frk	pituitary forkhead factor
putative transcription factor foxl2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05062	FOXL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20023	Foxl2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26526	Foxl2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxl2	NCBI	NCBI:668

Name
Email *

	Sorry, but the email address you supplied was invalid.