Hspa4 - heat shock protein family A (Hsp70) member 4 Gene

Rattus norvegicus

Also known as Hsp70; irp94; Hsp110

Gene ID: 266759 | Gene type: protein coding

About Hspa4

Primary_assembly 10: 37,408,025-37,449,001 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 294 orthologues, 13 paralogues and is associated with 18 phenotypes. Biased expression in Kidney (RPKM 486.9), Adrenal (RPKM 469.5) and 9 other tissues.

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including negative regulation of DNA binding activity; negative regulation of macromolecule metabolic process; and positive regulation of angiogenesis. Located in cytosol; lipid droplet; and nucleus. Used to study adult respiratory distress syndrome and middle cerebral artery infarction. Biomarker of Parkinson's disease and liver benign neoplasm. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (HSP70) member 4). [provided by Alliance of Genome Resources, Apr 2022]

Hspa4 Products(1)

mRNA	Protein	Name
NM_153629.1	NP_705893.1	heat shock 70 kDa protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17473852	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17473852	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	21561597	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in kidney development	IEP IEP: Inferred from expression pattern	21938673	RGD
involved in negative regulation of apoptotic process	IEP IEP: Inferred from expression pattern	21857080	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17473852	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17473852	RGD
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17473852	RGD
involved in positive regulation of angiogenesis	IEP IEP: Inferred from expression pattern	22098710	RGD
involved in regulation of microglial cell activation	IMP IMP: Inferred from mutant phenotype	17473852	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in lipid droplet	IDA IDA: Inferred from direct assay	17175194	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hspa4 Protein Structure

HSPA4_NBD

PTZ00121

0
200
400
600
840 a.a.

Protein Preferred Names

Protein Names

heat shock 70 kDa protein 4

heat shock protein 4	heat shock protein family A member 4
ischemia responsive 94 kDa protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06428	HSPA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06429	Hspa4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06430	Hspa4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06431	HSPA4L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21867	Hspa4l Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hspa4	NCBI	NCBI:3308

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