2. Gene
  3. RGL4 - ral guanine nucleotide dissociation stimulator like 4 Gene

RGL4 - ral guanine nucleotide dissociation stimulator like 4 Gene

  • Gene
  • Protein
  • Agent
Homo sapiens

Also known as Rgr

Gene ID: 266747 | Gene type: protein coding

About RGL4

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,691,013-23,699,168 (from NCBI)

This gene has 10 transcripts (splice variants), 22 orthologues and 24 paralogues. Ubiquitous expression in bone marrow (RPKM 20.9), appendix (RPKM 6.7) and 23 other tissues.

Summary

This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016]

RGL4 Products(3)

mRNA Protein Name
NM_001329424.3 NP_001316353.1 ral-GDS-related protein isoform 1 precursor
NM_001329425.2 NP_001316354.1 ral-GDS-related protein isoform 3
NM_153615.2 NP_705843.1 ral-GDS-related protein isoform 2 precursor

RGL4 Protein Structure

RasGEF

RasGEF: RasGEF domain (217 - 420)

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  • 473 a.a.
Protein Preferred Names Protein Names

ral-GDS-related protein

Ral-GDS related protein Rgr

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11893 RGL4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown