Nr5a1 - nuclear receptor subfamily 5, group A, member 1 Gene

Mus musculus

Also known as ELP; SF1; SF-1; Ad4BP; ELP-3; Ftzf1; STF-1; Ftz-F1

Gene ID: 26423 | Gene type: protein coding

About Nr5a1

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in negative regulation of female gonad development and positive regulation of male gonad development. Acts upstream of or within several processes, including adrenal gland development; gonad development; and maintenance of protein location in nucleus. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; endocrine gland; genitourinary system; hemolymphoid system; and respiratory system. Used to study hypogonadotropic hypogonadism. Human ortholog(s) of this gene implicated in 46,XX sex reversal 4; 46,XY sex reversal 3; Zellweger syndrome; primary ovarian insufficiency 7; and spermatogenic failure 8. Orthologous to human NR5A1 (nuclear receptor subfamily 5 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr5a1 Products(2)

mRNA	Protein	Name
NM_001316687.1	NP_001303616.1	steroidogenic factor 1
NM_139051.3	NP_620639.1	steroidogenic factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12730328	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16109736	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12651892	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Leydig cell differentiation	IGI IGI: Inferred from genetic interaction	15829514	MGI
acts upstream of or within Sertoli cell differentiation	IGI IGI: Inferred from genetic interaction	15829514	MGI
acts upstream of or within adrenal gland development	IGI IGI: Inferred from genetic interaction	11796523	MGI
acts upstream of or within adrenal gland development	IMP IMP: Inferred from mutant phenotype	11796523	MGI
acts upstream of or within hormone metabolic process	IMP IMP: Inferred from mutant phenotype	21820362	MGI
acts upstream of or within luteinization	IMP IMP: Inferred from mutant phenotype	15118069	MGI
acts upstream of or within maintenance of protein location in nucleus	IDA IDA: Inferred from direct assay	12610109	MGI
acts upstream of or within male gonad development	IGI IGI: Inferred from genetic interaction	19457926	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	15118069	MGI
involved in negative regulation of female gonad development	IMP IMP: Inferred from mutant phenotype	19301398	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12730328	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19301398	MGI
involved in positive regulation of male gonad development	IMP IMP: Inferred from mutant phenotype	19301398	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10446902	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19389484	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21757499	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12651892	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12861022	MGI
acts upstream of or within reproductive process	IMP IMP: Inferred from mutant phenotype	21820362	MGI
acts upstream of or within tissue development	IMP IMP: Inferred from mutant phenotype	16176945	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	19389484	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10848616	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

steroidogenic factor 1

adrenal 4-binding protein	embryonal LTR-binding protein
embryonal long terminal repeat-binding protein	fushi tarazu 1 factor homolog
fushi tarazu factor homolog 1	steroid hormone receptor Ad4BP
steroid hydroxylase positive regulator

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115613	ML-180	Agonist	99.96%	Unkown
HY-107404	SID 7969543	Inhibitor	99.42%	Unkown
HY-131445	RJW100	Activator	99.93%	Unkown
HY-RS09553	NR5A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17509	Nr5a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23966	Nr5a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr5a1	NCBI	NCBI:2516

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