Got2 - glutamic-oxaloacetic transaminase 2 Gene

Rattus norvegicus

Also known as mAAT; ASPATA

Gene ID: 25721 | Gene type: protein coding

About Got2

Summary

Enables several functions, including L-aspartate:2-oxoglutarate aminotransferase activity; anion binding activity; and identical protein binding activity. Involved in several processes, including dicarboxylic acid metabolic process; lactation; and response to morphine. Located in several cellular components, including T-tubule; mitochondrial inner membrane; and perikaryon. Part of protein-containing complex. Biomarker of acute kidney failure; neurodegenerative disease; obesity; and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, Apr 2022]

Got2 Products(1)

mRNA	Protein	Name
NM_013177.2	NP_037309.1	aspartate aminotransferase, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA IDA: Inferred from direct assay	10395949	RGD
enables L-aspartate:2-oxoglutarate aminotransferase activity	IMP IMP: Inferred from mutant phenotype	12686151	RGD
enables amino acid binding	IDA IDA: Inferred from direct assay	14522984	RGD
enables carboxylic acid binding	IDA IDA: Inferred from direct assay	14522984	RGD
enables enzyme binding	IDA IDA: Inferred from direct assay	3997814	RGD
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	12686151	RGD
enables phospholipid binding	IDA IDA: Inferred from direct assay	3997814	RGD
enables pyridoxal phosphate binding	IDA IDA: Inferred from direct assay	14522984	RGD
enables pyridoxal phosphate binding	IMP IMP: Inferred from mutant phenotype	12686151	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamate biosynthetic process	IDA IDA: Inferred from direct assay	16489927	RGD
involved in amino acid metabolic process	IDA IDA: Inferred from direct assay	14522984	RGD
involved in aspartate metabolic process	IMP IMP: Inferred from mutant phenotype	12686151	RGD
involved in dicarboxylic acid metabolic process	IDA IDA: Inferred from direct assay	14522984	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	27317891	RGD
involved in lactation	IEP IEP: Inferred from expression pattern	28798692	RGD
involved in oxaloacetate metabolic process	IDA IDA: Inferred from direct assay	16489927	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	23743348	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	22028411	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	23743348	RGD
located in cell surface	IDA IDA: Inferred from direct assay	11962739	RGD
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	3997814	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	7838383	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	3997814	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	23743348	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aspartate aminotransferase, mitochondrial

FABP-1	FABPpm
Glutamate oxaloacetate transaminase 2, mitochondrial (aspartate aminotransferase 2)	fatty acid-binding protein
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	kynurenine aminotransferase 4
kynurenine a

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05606	GOT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17809	Got2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24277	Got2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Got2	NCBI	NCBI:2806

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