2. Gene
  3. Zeb1 - zinc finger E-box binding homeobox 1 Gene

Zeb1 - zinc finger E-box binding homeobox 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Tcf8; Zfhx1a; deltaEF1

Gene ID: 25705 | Gene type: protein coding

About Zeb1

Summary

Enables chromatin binding activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; regulation of transcription by RNA polymerase II; and response to activity. Located in nucleus. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Zeb1 Products(1)

mRNA Protein Name
NM_001308265.2 NP_001295194.1 zinc finger E-box-binding homeobox 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
16824956 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
8769566 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16824956 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15226419 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
16824956 RGD
involved in forebrain development IEP
IEP: Inferred from expression pattern
11731009 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11476947 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16824956 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
19366873 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
19366873 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger E-box-binding homeobox 1

TCF-8

transcription factor 8 (represses interleukin 2 expression)

zfhep

zinc finger homeodomain enhancer-binding protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0153 Naringin 99.65% Unkown
HY-W011338 Benzyl butyl phthalate Activator ≥97.0% Unkown
HY-131445 RJW100 Activator 99.93% Unkown
HY-RS16025 ZEB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W011338S Benzyl butyl phthalate-d4 / Unkown
HY-N0153R Naringin (Standard) / Unkown
HY-RS16881 Zeb1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23323 Zeb1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zeb1 NCBI NCBI:6935