Otc - ornithine transcarbamylase Gene

Rattus norvegicus

Gene ID: 25611 | Gene type: protein coding

About Otc

Summary

Enables several functions, including identical protein binding activity; ornithine carbamoyltransferase activity; and phosphate ion binding activity. Involved in several processes, including alpha-amino acid metabolic process; response to biotin; and urea cycle. Located in mitochondrial inner membrane. Used to study ornithine carbamoyltransferase deficiency. Biomarker of cholestasis; fatty liver disease; and obesity. Human ortholog(s) of this gene implicated in ornithine carbamoyltransferase deficiency. Orthologous to human OTC (ornithine transcarbamylase). [provided by Alliance of Genome Resources, Apr 2022]

Otc Products(1)

mRNA	Protein	Name
NM_013078.2	NP_037210.1	ornithine transcarbamylase, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amino acid binding	IMP IMP: Inferred from mutant phenotype	2290837	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	2290837	RGD
enables ornithine carbamoyltransferase activity	IDA IDA: Inferred from direct assay	3680220	RGD
enables ornithine carbamoyltransferase activity	IMP IMP: Inferred from mutant phenotype	2290837	RGD
enables phosphate ion binding	IMP IMP: Inferred from mutant phenotype	2290837	RGD
enables phospholipid binding	IDA IDA: Inferred from direct assay	3680220	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in citrulline biosynthetic process	IDA IDA: Inferred from direct assay	9472964	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	8690412	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	9544996	RGD
involved in monoatomic anion homeostasis	IDA IDA: Inferred from direct assay	4062872	RGD
involved in ornithine metabolic process	IDA IDA: Inferred from direct assay	4062872	RGD
involved in response to biotin	IEP IEP: Inferred from expression pattern	8558326	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	9628242	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	9628242	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	14625847	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	11686784	RGD
involved in urea cycle	IDA IDA: Inferred from direct assay	3680220	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	3680220	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ornithine transcarbamylase, mitochondrial

OTCase

ornithine carbamoyltransferase, mitochondrial

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125947	4-Epioxytetracycline		99.16%	Unkown
HY-RS09859	OTC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17937	Otc Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24408	Otc Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Otc	NCBI	NCBI:5009
Mus musculus	Otc	NCBI	NCBI:18416

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