2. Gene
  3. Hbegf - heparin-binding EGF-like growth factor Gene

Hbegf - heparin-binding EGF-like growth factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Dtr; GFHB; Hegfl; Hb-egf

Gene ID: 25433 | Gene type: protein coding

About Hbegf

Summary

Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in epidermal growth factor receptor signaling pathway; negative regulation of elastin biosynthetic process; and positive regulation of cell growth. Predicted to be located in cell surface. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Hbegf Products(1)

mRNA Protein Name
NM_012945.2 NP_037077.1 proheparin-binding EGF-like growth factor precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables epidermal growth factor receptor binding IMP
IMP: Inferred from mutant phenotype
15486316 RGD
enables growth factor activity IMP
IMP: Inferred from mutant phenotype
15486316 RGD
Biological Process GO Annotation Evidence Reference Source
involved in epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15486316 RGD
involved in negative regulation of elastin biosynthetic process IDA
IDA: Inferred from direct assay
12882762 RGD
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
11956950 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proheparin-binding EGF-like growth factor

Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)

heparin binding epidermal growth factor-like growth factor

heparin-binding epidermal -growth - like growth factor

heparin-binding epidermal -growth factor

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06029 HBEGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17058 Hbegf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23502 Hbegf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hbegf NCBI NCBI:1839
Mus musculus Hbegf NCBI NCBI:15200