Dpysl3 - dihydropyrimidinase-like 3 Gene

Rattus norvegicus

Also known as Crmp4; TUC-4b

Gene ID: 25418 | Gene type: protein coding

About Dpysl3

Summary

Enables SH3 domain binding activity; chondroitin sulfate binding activity; and identical protein binding activity. Involved in several processes, including actin filament organization; regulation of plasma membrane bounded cell projection organization; and response to axon injury. Located in several cellular components, including cell body; growth cone; and lamellipodium. Part of filamentous actin. Is active in synapse. Colocalizes with exocytic vesicle. Orthologous to human DPYSL3 (dihydropyrimidinase like 3). [provided by Alliance of Genome Resources, Apr 2022]

Dpysl3 Products(2)

mRNA	Protein	Name
NM_001398556.1	NP_001385485.1	dihydropyrimidinase-related protein 3 isoform 2
NM_012934.2	NP_037066.1	dihydropyrimidinase-related protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IDA IDA: Inferred from direct assay	12684468	RGD
enables chondroitin sulfate binding	IDA IDA: Inferred from direct assay	12444086	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16181627	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin crosslink formation	IDA IDA: Inferred from direct assay	16181627	RGD
involved in actin filament bundle assembly	IDA IDA: Inferred from direct assay	16181627	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	20800647	RGD
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	16181627	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17301178	RGD
involved in neuron development	IEP IEP: Inferred from expression pattern	8815901	RGD
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	17301178	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	12684468	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	20800647	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body	IDA IDA: Inferred from direct assay	16181627	RGD
located in cytosol	IDA IDA: Inferred from direct assay	16181627	RGD
located in exocytic vesicle	IDA IDA: Inferred from direct assay	12684468	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	12444086	RGD
part of filamentous actin	IDA IDA: Inferred from direct assay	16181627	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12684468	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	16181627	RGD
is active in synapse	EXP EXP: Inferred from Experiment	15169875	RGD
is active in synapse	IDA IDA: Inferred from direct assay	15169875	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dihydropyrimidinase-related protein 3

CRMP-4	DRP-3
TOAD-64/Ulip/CRMP protein 4b	collapsin response mediator protein 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03982	DPYSL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20151	Dpysl3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26655	Dpysl3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dpysl3	NCBI	NCBI:1809

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