Dpysl2 - dihydropyrimidinase-like 2 Gene

Rattus norvegicus

Also known as Crmp2; TOAD-64

Gene ID: 25416 | Gene type: protein coding

About Dpysl2

Summary

Predicted to enable identical protein binding activity and protein kinase binding activity. Involved in several processes, including central nervous system development; positive regulation of glutamate secretion; and response to amphetamine. Located in several cellular components, including growth cone; myelin sheath; and neuronal cell body. Part of protein-containing complex. Is active in presynapse. Colocalizes with terminal bouton. Biomarker of brain ischemia; hypothyroidism; and status epilepticus. Orthologous to human DPYSL2 (dihydropyrimidinase like 2). [provided by Alliance of Genome Resources, Apr 2022]

Dpysl2 Products(1)

mRNA	Protein	Name
NM_001105717.2	NP_001099187.1	dihydropyrimidinase-related protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9375656	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in olfactory bulb development	IEP IEP: Inferred from expression pattern	14751288	RGD
involved in positive regulation of glutamate secretion	IDA IDA: Inferred from direct assay	19755421	RGD
involved in regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18218617	RGD
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	29425794	RGD
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	29425794	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	20058175	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	19457111	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	12188101	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	8946055	RGD
involved in synaptic vesicle transport	IDA IDA: Inferred from direct assay	19755421	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	19755421	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	29425794	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	29425794	RGD
located in growth cone	IDA IDA: Inferred from direct assay	7472434	RGD
located in myelin sheath	IDA IDA: Inferred from direct assay	17960831	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19457111	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	19755421	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19755421	RGD
is active in synapse	IDA IDA: Inferred from direct assay	19755421	RGD
is active in synapse	IMP IMP: Inferred from mutant phenotype	19755421	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	19755421	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dihydropyrimidinase-related protein 2

CRMP-2	DRP-2
collapsin response mediator protein 2	turned on after division, 64 kDa protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03981	DPYSL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18860	Dpysl2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25352	Dpysl2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dpysl2	NCBI	NCBI:1808

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