2. Gene
  3. Phb1 - prohibitin 1 Gene

Phb1 - prohibitin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Phb

Gene ID: 25344 | Gene type: protein coding

About Phb1

Summary

Predicted to enable several functions, including complement binding activity; histone deacetylase binding activity; and protein C-terminus binding activity. Involved in several processes, including female gonad development; positive regulation of protein kinase B signaling; and positive regulation of smooth muscle cell proliferation. Located in mitochondrial crista and nucleus. Is extrinsic component of mitochondrial outer membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is extrinsic component of presynaptic active zone membrane. Biomarker of urinary bladder Cancer. Human ortholog(s) of this gene implicated in breast Cancer and sporadic breast Cancer. Orthologous to human PHB (prohibitin). [provided by Alliance of Genome Resources, Apr 2022]

Phb1 Products(1)

mRNA Protein Name
NM_031851.2 NP_114039.1 prohibitin 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
9473733 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17038561 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17043753 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17043753 RGD
involved in ovarian follicle atresia IEP
IEP: Inferred from expression pattern
15028627 RGD
involved in ovarian follicle development IEP
IEP: Inferred from expression pattern
15028627 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
32173312 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
32173312 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
17043753 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16825707 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
15378698 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
12639934 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16470657 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
23622064 RGD
is active in extrinsic component of presynaptic active zone membrane EXP
EXP: Inferred from Experiment
23622064 RGD
is active in extrinsic component of presynaptic active zone membrane IDA
IDA: Inferred from direct assay
23622064 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
17623647 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17623647 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
7843414 RGD
is active in postsynaptic density EXP
EXP: Inferred from Experiment
17623647 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
17623647 RGD
is active in synapse IDA
IDA: Inferred from direct assay
18504422 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prohibitin 1

prohibitin

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114989 Fluorizoline Inducer 99.77% Unkown
HY-141475 Acetoacetyl coenzyme A sodium / Unkown
HY-162904 BPU17 / Unkown
HY-RS10407 PHB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17295 Phb1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23750 Phb1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phb1 NCBI NCBI:5245
Mus musculus Phb1 NCBI
Macaca mulatta Phb1 NCBI NCBI:699334