Nr1d1 - nuclear receptor subfamily 1, group D, member 1 Gene

Rattus norvegicus

Also known as REV-ERBAALPHA

Gene ID: 252917 | Gene type: protein coding

About Nr1d1

Summary

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor Aryl Hydrocarbon Receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014]

Nr1d1 Products(2)

mRNA	Protein	Name
NM_001113422.2	NP_001106893.2	nuclear receptor subfamily 1 group D member 1 isoform 1
NM_145775.3	NP_665718.2	nuclear receptor subfamily 1 group D member 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21874017	RGD
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	8474464	RGD
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	8015547	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	24144766	RGD
involved in photoperiodism	IEP IEP: Inferred from expression pattern	21076970	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22425774	RGD
involved in positive regulation of circadian rhythm	IDA IDA: Inferred from direct assay	18946026	RGD
involved in regulation of circadian rhythm	IDA IDA: Inferred from direct assay	22425774	RGD
involved in regulation of hepatic stellate cell activation	IDA IDA: Inferred from direct assay	24497272	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	21874017	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	21874017	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor subfamily 1 group D member 1

EAR-1	V-erbA-related protein 1
V-erbA-related protein EAR-1	rev-erb alpha
rev-erbA-alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09527	NR1D1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18073	Nr1d1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24548	Nr1d1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr1d1	NCBI	NCBI:9572

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