Rxra - retinoid X receptor alpha Gene

Rattus norvegicus

Gene ID: 25271 | Gene type: protein coding

About Rxra

Summary

Enables protein domain specific binding activity and retinoic acid receptor binding activity. Contributes to double-stranded DNA binding activity. Involved in several processes, including cellular response to Insulin stimulus; response to retinoic acid; and response to vitamin. Located in axon and nucleus. Biomarker of alcoholic cardiomyopathy and prostate carcinoma in situ. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human RXRA (retinoid X receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Rxra Products(1)

mRNA	Protein	Name
NM_012805.3	NP_036937.2	retinoic acid receptor RXR-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to double-stranded DNA binding	IDA IDA: Inferred from direct assay	17483744	RGD
enables nuclear retinoic acid receptor binding	IPI IPI: Inferred from physical interaction	15234273	RGD
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	10037764	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9199332	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	9742117	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15234273	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon regeneration	IEP IEP: Inferred from expression pattern	16782282	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	9555940	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	16135695	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	14729401	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	15964596	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16344269	RGD
involved in placenta development	IEP IEP: Inferred from expression pattern	16135695	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16344269	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12105223	RGD
involved in regulation of myelination	IDA IDA: Inferred from direct assay	20648638	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	19791468	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	17483744	RGD
involved in response to glucocorticoid	IMP IMP: Inferred from mutant phenotype	19008781	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	14986719	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17270546	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	9555940	RGD
involved in response to selenium ion	IEP IEP: Inferred from expression pattern	15318950	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	16180333	RGD
involved in response to vitamin D	IEP IEP: Inferred from expression pattern	12048211	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16782282	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

retinoic acid receptor RXR-alpha

nuclear receptor subfamily 2 group B member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12361	RXRA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121435	K-8012		98.24%	Unkown
HY-160212	JP3000	Agonist	/	Unkown
HY-RS17966	Rxra Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24437	Rxra Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rxra	NCBI	NCBI:6256

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