Pcsk1 - proprotein convertase subtilisin/kexin type 1 Gene

Rattus norvegicus

Also known as BDP; PC1; PC3

Gene ID: 25204 | Gene type: protein coding

About Pcsk1

Summary

Enables endopeptidase activity. Involved in several processes, including nervous system development; protein processing; and response to morphine. Located in several cellular components, including perikaryon; rough endoplasmic reticulum; and trans-Golgi network. Colocalizes with secretory granule. Used to study hyperglycemia and type 2 diabetes mellitus. Biomarker of glucose metabolism disease (multiple); hyperthyroidism; hypothyroidism; islet cell tumor; and visual epilepsy. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk1 Products(1)

mRNA	Protein	Name
NM_017091.2	NP_058787.1	neuroendocrine convertase 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	10087454	RGD
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	9556596	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in neurogenesis	IEP IEP: Inferred from expression pattern	18781386	RGD
involved in pancreas development	IEP IEP: Inferred from expression pattern	17221210	RGD
involved in peptide hormone processing	IDA IDA: Inferred from direct assay	10087454	RGD
involved in peptide hormone processing	IMP IMP: Inferred from mutant phenotype	16497799	RGD
involved in pituitary gland development	IEP IEP: Inferred from expression pattern	15208361	RGD
involved in positive regulation of protein secretion	IDA IDA: Inferred from direct assay	9389490	RGD
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	12721373	RGD
involved in protein autoprocessing	IMP IMP: Inferred from mutant phenotype	9556596	RGD
involved in protein processing	IMP IMP: Inferred from mutant phenotype	16497799	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	18585435	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	9556596	RGD
involved in response to chlorate	IEP IEP: Inferred from expression pattern	17221210	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	18781386	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	11751617	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	17283238	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	17283238	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	10630414	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	17584972	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	10971617	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	17584972	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	10971617	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IDA IDA: Inferred from direct assay	10906712	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10906712	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	9389490	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10906712	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	17543468	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9389490	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	7822759	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	10906712	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuroendocrine convertase 1

NEC 1	Protein convertase subtilisin / kexin, type I
prohormone convertase 1	prohormone convertase 3
proprotein convertase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10170	PCSK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10171	PCSK1N Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18538	Pcsk1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25020	Pcsk1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pcsk1	NCBI	NCBI:5122

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