Glul - glutamate-ammonia ligase Gene

Rattus norvegicus

Also known as Glns

Gene ID: 24957 | Gene type: protein coding

About Glul

Summary

Enables several functions, including anion binding activity; dynein light chain binding activity; and metal ion binding activity. Involved in glutamine metabolic process; positive regulation of cell communication; and positive regulation of epithelial cell proliferation. Located in several cellular components, including myelin sheath; perikaryon; and rough endoplasmic reticulum. Part of protein-containing complex. Used to study obesity; temporal lobe epilepsy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Orthologous to human GLUL (glutamate-ammonia Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Glul Products(2)

mRNA	Protein	Name
NM_001393804.1	NP_001380733.1	glutamine synthetase
NM_017073.4	NP_058769.4	glutamine synthetase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	28323	RGD
enables dynein light chain binding	IPI IPI: Inferred from physical interaction	14760703	RGD
enables glutamate binding	IDA IDA: Inferred from direct assay	28323	RGD
enables glutamine synthetase activity	IDA IDA: Inferred from direct assay	28323	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	28323	RGD
enables magnesium ion binding	IDA IDA: Inferred from direct assay	28323	RGD
enables manganese ion binding	IDA IDA: Inferred from direct assay	28323	RGD
enables nickel cation binding	IDA IDA: Inferred from direct assay	21254280	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ammonia assimilation cycle	IDA IDA: Inferred from direct assay	28323	RGD
involved in glutamate metabolic process	IDA IDA: Inferred from direct assay	4403443	RGD
involved in glutamine biosynthetic process	IDA IDA: Inferred from direct assay	28323	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	9915876	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	12575909	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	10696145	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
NOT located in axon terminus	IDA IDA: Inferred from direct assay	31966	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	6105901	RGD
located in cell projection	IDA IDA: Inferred from direct assay	31966	RGD
located in myelin sheath	IDA IDA: Inferred from direct assay	17960831	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	31966	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	28323	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamine synthetase

GS	Glutamine synthetase (glutamate-ammonia ligase)
glutamate decarboxylase	glutamate-ammonia ligase (glutamine synthase)
glutamate-ammonia ligase (glutamine synthetase)	glutamine synthetase 1
palmitoyltransferase GLUL

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05509	GLUL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17491	Glul Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23948	Glul Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Glul	NCBI	NCBI:2752

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