Srd5a1 - steroid 5 alpha-reductase 1 Gene

Rattus norvegicus

Also known as S5AR 1

Gene ID: 24950 | Gene type: protein coding

About Srd5a1

Summary

Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity; NADPH binding activity; and amide binding activity. Involved in several processes, including animal organ development; cellular hormone metabolic process; and cellular response to organic cyclic compound. Located in several cellular components, including cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Used to study prostate Cancer. Biomarker of hyperprolactinemia; hypothyroidism; obesity; prostate cancer; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in prostate Cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1). [provided by Alliance of Genome Resources, Apr 2022]

Srd5a1 Products(1)

mRNA	Protein	Name
NM_017070.3	NP_058766.2	3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IDA IDA: Inferred from direct assay	7482629	RGD
enables NADPH binding	IDA IDA: Inferred from direct assay	11377984	RGD
enables amide binding	IDA IDA: Inferred from direct assay	9090798	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in androgen biosynthetic process	IDA IDA: Inferred from direct assay	12606426	RGD
involved in androgen catabolic process	IDA IDA: Inferred from direct assay	2339109	RGD
involved in androgen metabolic process	IDA IDA: Inferred from direct assay	20954080	RGD
involved in bone development	IEP IEP: Inferred from expression pattern	15012600	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	14997014	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	15004407	RGD
involved in cellular response to epinephrine stimulus	IEP IEP: Inferred from expression pattern	14997014	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	15312799	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	15249139	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	20810561	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	15936112	RGD
involved in cellular response to starvation	IEP IEP: Inferred from expression pattern	9729333	RGD
involved in cellular response to testosterone stimulus	IEP IEP: Inferred from expression pattern	15004407	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	8770891	RGD
involved in diterpenoid metabolic process	IEP IEP: Inferred from expression pattern	14997014	RGD
involved in female genitalia development	IEP IEP: Inferred from expression pattern	9142501	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	8770891	RGD
involved in hypothalamus development	IEP IEP: Inferred from expression pattern	8770891	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	8770891	RGD
involved in male genitalia development	IEP IEP: Inferred from expression pattern	9142501	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	12606426	RGD
involved in pituitary gland development	IEP IEP: Inferred from expression pattern	8770891	RGD
involved in progesterone metabolic process	IDA IDA: Inferred from direct assay	9202401	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	9504773	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	19793540	RGD
involved in response to follicle-stimulating hormone	IEP IEP: Inferred from expression pattern	12630924	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	19728174	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	10067850	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	20045012	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17940878	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	16595696	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	1314830	RGD
involved in serotonin metabolic process	IEP IEP: Inferred from expression pattern	15936112	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	8770891	RGD
involved in steroid biosynthetic process	IDA IDA: Inferred from direct assay	7482629	RGD
involved in thalamus development	IEP IEP: Inferred from expression pattern	8770891	RGD
involved in urogenital system development	IEP IEP: Inferred from expression pattern	8584033	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body fiber	IDA IDA: Inferred from direct assay	15305365	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15305365	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	7553073	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

3-oxo-5-alpha-steroid 4-dehydrogenase 1

SR type 1

steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152094	SRD5A1-IN-1	Inhibitor	99.82%	Unkown
HY-RS13754	SRD5A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19076	Srd5a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25567	Srd5a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Srd5a1	NCBI	NCBI:6715

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