Hnf1a - HNF1 homeobox A Gene

Rattus norvegicus

Also known as HNF1; Lfb1; Tcf1; LF-B1

Gene ID: 24817 | Gene type: protein coding

About Hnf1a

Summary

Enables DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in chromatin and nucleus. Part of protein-containing complex. Used to study hepatocellular adenoma and hepatocellular carcinoma. Biomarker of extrahepatic cholestasis and kidney disease. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); liver disease (multiple); and renal cell carcinoma. Orthologous to human HNF1A (HNF1 homeobox A). [provided by Alliance of Genome Resources, Apr 2022]

Hnf1a Products(1)

mRNA	Protein	Name
NM_012669.1	NP_036801.1	hepatocyte nuclear factor 1-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1763325	RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20735474	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	1763325	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	14561216	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12753154	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	15598887	RGD
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	15598887	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	20841353	RGD
involved in apoptotic nuclear changes	IMP IMP: Inferred from mutant phenotype	20841353	RGD
involved in cellular response to L-leucine	IMP IMP: Inferred from mutant phenotype	21874357	RGD
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	20841353	RGD
involved in cellular response to rapamycin	IMP IMP: Inferred from mutant phenotype	21874357	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20841353	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	21874357	RGD
involved in negative regulation of miRNA processing	IMP IMP: Inferred from mutant phenotype	23674172	RGD
involved in negative regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	20841353	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7937157	RGD
involved in positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	20841353	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20841353	RGD
involved in positive regulation of insulin secretion	IEP IEP: Inferred from expression pattern	10944108	RGD
involved in positive regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	10944108	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	21874357	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	21874357	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7937157	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15598887	RGD
involved in regulation of NADP metabolic process	IMP IMP: Inferred from mutant phenotype	20841353	RGD
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14561216	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	15598887	RGD
located in nucleus	IDA IDA: Inferred from direct assay	1763325	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15598887	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 1-alpha

HNF-1-alpha	HNF-1A
LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1	TCF-1
Transcription factor 1, hepatic	albumin proximal factor
hepatic nuclear factor 1	hepatic nuclear factor-1-alpha
liver-specific transcription factor L

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06255	HNF1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19690	Hnf1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26185	Hnf1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnf1a	NCBI	NCBI:6927

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